| First Author | Bialuk I | Year | 2019 |
| Journal | Behav Genet | Volume | 49 |
| Issue | 4 | Pages | 415-423 |
| PubMed ID | 31129771 | Mgi Jnum | J:289266 |
| Mgi Id | MGI:6434922 | Doi | 10.1007/s10519-019-09959-6 |
| Citation | Bialuk I, et al. (2019) Significance of IL-6 Deficiency in Recognition Memory in Young Adult and Aged Mice. Behav Genet 49(4):415-423 |
| abstractText | Chronic peripheral elevation of interleukin 6 (IL-6) in humans is associated with cognitive deficits. 4- and 24-month-old IL-6-deficient C57BL/6J (IL-6KO) and reference wild-type (WT) mice were tested in an object recognition test. Discrimination ratios and recognition indexes were significantly lower in 4-month-old IL-6KO and in 24-month-old WT mice vs 4-month-old WT animals. Their discrimination ratios had negative values and recognition indexes were below 50% indicating inability to differentiate the novel from the familiar object after 1-hour delay. In 24-month-old IL-6KO mice recognition index reached 53.17% indicating that their recognition memory was not worsened with age in comparison with younger IL-6-deficient animals. Results of holeboard and elevated plus maze indicated that this effect was memory specific. Inborn IL-6 deficiency attenuated recognition memory in 4-month-old mice and did not altered recognition memory in aged animals. IL-6 signalling may constitute a target for development of the protection against memory disturbances connected with IL-6 overexpression. |
