| First Author | Cenci E | Year | 2001 |
| Journal | J Infect Dis | Volume | 184 |
| Issue | 5 | Pages | 610-7 |
| PubMed ID | 11494166 | Mgi Jnum | J:120152 |
| Mgi Id | MGI:3703956 | Doi | 10.1086/322793 |
| Citation | Cenci E, et al. (2001) Impaired antifungal effector activity but not inflammatory cell recruitment in interleukin-6-deficient mice with invasive pulmonary aspergillosis. J Infect Dis 184(5):610-7 |
| abstractText | A murine model of infection, in which immunocompetent or immunosuppressed interleukin-6-deficient (IL-6(-/-)) mice were infected intranasally with Aspergillus fumigatus conidia and were monitored for parameters of fungal colonization and innate and adaptive immunity, was used to assess the role of IL-6 in invasive pulmonary aspergillosis (IPA). The results indicate that IL-6(-/-) mice were more susceptible than wild-type mice to IPA. Susceptibility was associated with increased inflammatory pathology, decreased antifungal effector functions of phagocytes, and impaired development of protective type 1 responses. Exposure to exogenous IL-6 restored antifungal effector activity. |
