| First Author | Storer MA | Year | 2018 |
| Journal | Stem Cell Reports | Volume | 10 |
| Issue | 5 | Pages | 1464-1480 |
| PubMed ID | 29628394 | Mgi Jnum | J:271021 |
| Mgi Id | MGI:6269115 | Doi | 10.1016/j.stemcr.2018.03.008 |
| Citation | Storer MA, et al. (2018) Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development. Stem Cell Reports 10(5):1464-1480 |
| abstractText | Circulating systemic factors can regulate adult neural stem cell (NSC) biology, but the identity of these circulating cues is still being defined. Here, we have focused on the cytokine interleukin-6 (IL-6), since increased circulating levels of IL-6 are associated with neural pathologies such as autism and bipolar disorder. We show that IL-6 promotes proliferation of post-natal murine forebrain NSCs and that, when the IL-6 receptor is inducibly knocked out in post-natal or adult neural precursors, this causes a long-term decrease in forebrain NSCs. Moreover, a transient circulating surge of IL-6 in perinatal or adult mice causes an acute increase in neural precursor proliferation followed by long-term depletion of adult NSC pools. Thus, IL-6 signaling is both necessary and sufficient for adult NSC self-renewal, and acute perturbations in circulating IL-6, as observed in many pathological situations, have long-lasting effects on the size of adult NSC pools. |
