| First Author | Agthe M | Year | 2017 |
| Journal | Placenta | Volume | 57 |
| Pages | 13-16 | PubMed ID | 28864002 |
| Mgi Jnum | J:271083 | Mgi Id | MGI:6279601 |
| Doi | 10.1016/j.placenta.2017.05.015 | Citation | Agthe M, et al. (2017) Interleukin-11 classic but not trans-signaling is essential for fertility in mice. Placenta 57:13-16 |
| abstractText | The cytokine interleukin (IL)-11 activates its target cells through binding to the membrane-bound IL-11 receptor (IL-11R). Female mice deficient in IL-11R (Il11ra(-/-)) are infertile due to a defect in decidualization when the blastocyst implants. We have recently shown that IL-11 can also signal via a soluble IL-11R (trans-signaling). Which IL-11 pathway is required for fertility in mice is unknown. We confirm that female Il11ra(-/-)mice, lacking both classic and trans-signaling, are infertile. In contrast, the selective blockade of IL-11 trans-signaling does not affect fertility in mice. These results show that classic, but not trans-signaling of IL-11, is essential for fertility in mice. |
