| First Author | Maeda K | Year | 2005 |
| Journal | Blood | Volume | 106 |
| Issue | 3 | Pages | 879-85 |
| PubMed ID | 15831701 | Mgi Jnum | J:117320 |
| Mgi Id | MGI:3695993 | Doi | 10.1182/blood-2005-02-0456 |
| Citation | Maeda K, et al. (2005) IL-6 blocks a discrete early step in lymphopoiesis. Blood 106(3):879-85 |
| abstractText | Animals lacking Src homology 2 domain-containing inositol 5-phosphatase (SHIP) display a reduction in lymphopoiesis and a corresponding enhancement of myelopoiesis. These effects are mediated at least in part by elevated levels of interleukin 6 (IL-6). Here, we show the lymphopoiesis block in SHIP-/- mice is due to suppression of the lymphoid lineage choice by uncommitted progenitors. The suppression can be reproduced in vitro with recombinant IL-6, and IL-6 acts directly on hematopoietic progenitors. The block is partially overcome in SHIP-/- IL-6-/- double-deficient animals. IL-6 does not suppress but actually enhances proliferation of lymphoid-committed progenitors, indicating the IL-6 target cells are hematopoietic stem cells or multipotent progenitors. The findings suggest a mechanism for the lymphopenia that accompanies proinflammatory diseases. |
