| First Author | Sin SH | Year | 2015 |
| Journal | J Virol | Volume | 90 |
| Issue | 4 | Pages | 2150-4 |
| PubMed ID | 26656696 | Mgi Jnum | J:237656 |
| Mgi Id | MGI:5816419 | Doi | 10.1128/JVI.02456-15 |
| Citation | Sin SH, et al. (2015) Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Compensates for Interleukin-6 in Initial B Cell Activation. J Virol 90(4):2150-4 |
| abstractText | Interleukin 6 (IL-6) is considered a proliferation and survival factor for B cells. To assess the role of IL-6 in Kaposi sarcoma-associated herpesvirus (KSHV) latency, KSHV latency locus-transgenic mice (referred to as latency mice) lacking IL-6 were evaluated. IL-6(-/-) latency mice had the same phenotypes as the latency mice, i.e., increased frequency of marginal zone B cells, hyperplasia, and hyperglobulinemia, indicating that the KSHV latency locus, which includes all viral microRNAs (miRNAs), can compensate for lack of IL-6 in premalignant B cell activation. |
