| First Author | Diao H | Year | 2005 |
| Journal | Infect Immun | Volume | 73 |
| Issue | 6 | Pages | 3745-8 |
| PubMed ID | 15908405 | Mgi Jnum | J:99141 |
| Mgi Id | MGI:3581338 | Doi | 10.1128/IAI.73.6.3745-3748.2005 |
| Citation | Diao H, et al. (2005) Endogenous interleukin-6 plays a crucial protective role in streptococcal toxic shock syndrome via suppression of tumor necrosis factor alpha production. Infect Immun 73(6):3745-8 |
| abstractText | During a Streptococcus pyogenes infection in interleukin-6 (IL-6)-deficient mice, there is elevation of serum tumor necrosis factor alpha (TNF-alpha) levels, muscular necrosis, and death compared with infection of C57BL/6 mice. Anti-TNF-alpha monoclonal antibody treatment decreased mortality and muscular necrosis in the infected IL-6-deficient mice. These results suggest that IL-6 plays a crucial protective role via suppression of TNF-alpha production in S. pyogenes infection. |
