| First Author | von Freeden-Jeffry U | Year | 1997 |
| Journal | Immunity | Volume | 7 |
| Issue | 1 | Pages | 147-54 |
| PubMed ID | 9252127 | Mgi Jnum | J:42039 |
| Mgi Id | MGI:894974 | Doi | 10.1016/s1074-7613(00)80517-8 |
| Citation | von Freeden-Jeffry U, et al. (1997) The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity 7(1):147-54 |
| abstractText | Interleukin-7 (IL-7)-deficient mice exhibit an early defect in lymphopoiesis. We examined Bcl-2 expression and the cell cycle status of immature thymocyte subsets in these mice. In IL-7-deficient mice, developmental transition to a T cell-committed fate was accompanied by a striking loss of Bcl-2 protein expression and an increased relative proportion of cells in the G0/G1 stage of the cell cycle. Short-term culture of immature thymocytes with rIL-7 caused up-regulation of Bcl-2 protein and cell survival. These data specify a T cell lineage developmental transition point, prior to T cell antigen receptor rearrangement, where IL-7 signal transduction is linked to an anti-apoptosis mechanism and the cell cycle. |
