| First Author | Serwold T | Year | 2009 |
| Journal | Blood | Volume | 113 |
| Issue | 4 | Pages | 807-15 |
| PubMed ID | 18927436 | Mgi Jnum | J:144570 |
| Mgi Id | MGI:3831229 | Doi | 10.1182/blood-2008-08-173682 |
| Citation | Serwold T, et al. (2009) Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis. Blood 113(4):807-15 |
| abstractText | Ongoing thymopoiesis requires continual seeding from progenitors that reside within the bone marrow (BM), but the identity of the most proximate prethymocytes has remained controversial. Here we take a comprehensive approach to prospectively identify the major source of thymocyte progenitors that reside within the BM and blood, and find that all thymocyte progenitor activity resides within a rare Flk2(+)CD27(+) population. The BM Flk2(+)CD27(+) subset is predominantly composed of common lymphoid progenitors (CLPs) and multipotent progenitors. Of these 2 populations, only CLPs reconstitute thymopoiesis rapidly after intravenous injection. In contrast, multipotent progenitor-derived cells reconstitute the thymus with delayed kinetics only after they have reseeded the BM, self-renewed, and generated CLPs. These results identify CLPs as the major source of thymocyte progenitors within the BM. |
