| First Author | Van Acker A | Year | 2017 |
| Journal | Cell Rep | Volume | 19 |
| Issue | 7 | Pages | 1431-1443 |
| PubMed ID | 28514662 | Mgi Jnum | J:256231 |
| Mgi Id | MGI:6103402 | Doi | 10.1016/j.celrep.2017.04.068 |
| Citation | Van Acker A, et al. (2017) A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties. Cell Rep 19(7):1431-1443 |
| abstractText | The Ly49E receptor is preferentially expressed on murine innate-like lymphocytes, such as epidermal Vgamma3 T cells, intestinal intraepithelial CD8alphaalpha(+) T lymphocytes, and CD49a(+) liver natural killer (NK) cells. As the latter have recently been shown to be distinct from conventional NK cells and have innate lymphoid cell type 1 (ILC1) properties, we investigated Ly49E expression on intestinal ILC populations. Here, we show that Ly49E expression is very low on known ILC populations, but it can be used to define a previously unrecognized intraepithelial innate lymphoid population. This Ly49E-positive population is negative for NKp46 and CD8alphaalpha, expresses CD49a and CD103, and requires T-bet expression and IL-15 signaling for differentiation and/or survival. Transcriptome analysis reveals a group 1 ILC gene profile, different from NK cells, iCD8alpha cells, and intraepithelial ILC1. Importantly, NKp46(-)CD8alphaalpha(-)Ly49E(+) cells produce interferon (IFN)-gamma, suggesting that this previously unrecognized population may contribute to Th1-mediated immunity. |
