| First Author | Kee BL | Year | 2002 |
| Journal | EMBO J | Volume | 21 |
| Issue | 1-2 | Pages | 103-13 |
| PubMed ID | 11782430 | Mgi Jnum | J:73902 |
| Mgi Id | MGI:2157171 | Doi | 10.1093/emboj/21.1.103 |
| Citation | Kee BL, et al. (2002) IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitors. EMBO J 21(1-2):103-13 |
| abstractText | Mice that lack the transcription factors encoded by the E2A gene or the receptor for interleukin 7 (IL-7R) have severe overlapping defects in lymphocyte development. Here, we show that E2A proteins are required for the survival of early T-lineage cells; however, they function through a pathway that is distinct from the survival pathway initiated by IL-7R signaling. While E2A proteins are required to suppress caspase 3 activation, ectopic expression of the anti-apoptotic protein Bcl-2 is not sufficient to overcome the lymphopoietic defects observed in the absence of E2A. Remarkably, mice that lack both IL-7Ralpha and E47 display a synergistic decrease in the number of T-cell, NK-cell and multipotent progenitors in the thymus, indicating that these distinct survival pathways converge to promote the development of multipotent lymphoid progenitors. |
