| First Author | Brockmann L | Year | 2023 |
| Journal | Immunity | Volume | 56 |
| Issue | 12 | Pages | 2719-2735.e7 |
| PubMed ID | 38039966 | Mgi Jnum | J:354472 |
| Mgi Id | MGI:7568728 | Doi | 10.1016/j.immuni.2023.11.003 |
| Citation | Brockmann L, et al. (2023) Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10. Immunity 56(12):2719-2735.e7 |
| abstractText | Commensal microbes induce cytokine-producing effector tissue-resident CD4(+) T cells, but the function of these T cells in mucosal homeostasis is not well understood. Here, we report that commensal-specific intestinal Th17 cells possess an anti-inflammatory phenotype marked by expression of interleukin (IL)-10 and co-inhibitory receptors. The anti-inflammatory phenotype of gut-resident commensal-specific Th17 cells was driven by the transcription factor c-MAF. IL-10-producing commensal-specific Th17 cells were heterogeneous and derived from a TCF1(+) gut-resident progenitor Th17 cell population. Th17 cells acquired IL-10 expression and anti-inflammatory phenotype in the small-intestinal lamina propria. IL-10 production by CD4(+) T cells and IL-10 signaling in intestinal macrophages drove IL-10 expression by commensal-specific Th17 cells. Intestinal commensal-specific Th17 cells possessed immunoregulatory functions and curbed effector T cell activity in vitro and in vivo in an IL-10-dependent and c-MAF-dependent manner. Our results suggest that tissue-resident commensal-specific Th17 cells perform regulatory functions in mucosal homeostasis. |
