| First Author | Huang JH | Year | 2021 |
| Journal | iScience | Volume | 24 |
| Issue | 2 | Pages | 102103 |
| PubMed ID | 33615201 | Mgi Jnum | J:307239 |
| Mgi Id | MGI:6717479 | Doi | 10.1016/j.isci.2021.102103 |
| Citation | Huang JH, et al. (2021) Regulatory T cells induced by B cells suppress NLRP3 inflammasome activation and alleviate monosodium urate-induced gouty inflammation. iScience 24(2):102103 |
| abstractText | Regulatory T cells induced by B cells (Treg-of-B cells), a distinct Foxp3(-) Treg cell subset, have established the roles in the suppression of inflammatory conditions, including asthma and intestinal inflammation. However, little is known about the regulatory effects of Treg-of-B cells on innate immunity. Herein, we examined whether Treg-of-B cells could regulate macrophage function and prevent NLRP3-associated diseases, particularly inflammatory gouty arthritis. Treg-of-B cells, but not thymus-derived Treg or effector T cells, inhibited inflammasome-mediated IL-1beta secretion, caspase-1 activation, and NLRP3 production by LPS/ATP stimulation in a cell contact-dependent manner. In addition, Treg-of-B cells inhibited monosodium urate-induced NLRP3 inflammasome activation in vitro via NF-kappaB signaling. Treg-of-B cells ameliorated gouty inflammation in a mouse air pouch model by reducing neutrophil and leukocyte influx and cytokine and chemokine production. Our results demonstrated that Treg-of-B cells exerted regulatory effects on innate immunity by suppressing NLRP3 inflammasome activation and feasible for future therapeutic applications. |
