| First Author | Fassbender M | Year | 2010 |
| Journal | Cell Immunol | Volume | 265 |
| Issue | 2 | Pages | 91-6 |
| PubMed ID | 20728078 | Mgi Jnum | J:165335 |
| Mgi Id | MGI:4837025 | Doi | 10.1016/j.cellimm.2010.07.007 |
| Citation | Fassbender M, et al. (2010) Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation. Cell Immunol 265(2):91-6 |
| abstractText | In humans and mice naturally occurring regulatory T cells (nTregs) are crucial for the maintenance of peripheral tolerance by controlling not only potentially autoreactive T cells but virtually all cells of the adaptive and innate immune system. Here we show that co-culture of murine dendritic cells (DC) and nTregs results in an immediate increase of cAMP in DC, responsible for a rapid down-regulation of co-stimulatory molecules (CD80, CD86). In addition, the inhibitory surface molecule B7-H3 on DC is up-regulated. Subsequently, nTreg-derived IL-10 inhibits the cytokine production (IL-6, IL-12) of suppressed DC therewith preserving their silent phenotype. Hence, our data indicate that nTregs effectively control exuberant immune responses by directly limiting the stimulatory capacity of DC via a sophisticated chronologic action of inhibitory signals. |
