| First Author | Tao L | Year | 2019 |
| Journal | Pharmacol Res | Volume | 148 |
| Pages | 104457 | PubMed ID | 31536782 |
| Mgi Jnum | J:293428 | Mgi Id | MGI:6452707 |
| Doi | 10.1016/j.phrs.2019.104457 | Citation | Tao L, et al. (2019) IL-10-producing regulatory B cells exhibit functional defects and play a protective role in severe endotoxic shock. Pharmacol Res 148:104457 |
| abstractText | Dysregulated host immune homeostasis in sepsis is life-threatening even after a successfully treated bacterial infection. Lipopolysaccharide (LPS) is an endotoxin that is a major contributor to the aberrant immune responses and endotoxic shock in gram-negative bacterial sepsis. However, the current knowledge of the role of B cells in endotoxic shock is limited. Here, we report that CD1d expression in B cells and the percentage of CD5(+)CD1d(hi) regulatory B (Breg) cells decreased in a mouse model of endotoxic shock. Interestingly, IL-10 but not FasL expression in CD5(+)CD1d(hi) Breg cells in response to endotoxin was dramatically reduced in severe septic shock mice, and the regulatory function of CD5(+)CD1d(hi) Breg cells in vitro to control the Th1 response was also diminished. Adoptive transfer of CD5(+)CD1d(hi) Breg cells from healthy WT mice but not IL-10 deficient mice downregulated the IFN-gamma secretion in CD4(+) T cells and conferred protection against severe endotoxic shock in vivo. Our findings demonstrate the change and notable therapeutic potential of IL-10-producing Breg cells in endotoxic shock. |
