| First Author | Takiishi T | Year | 2012 |
| Journal | J Leukoc Biol | Volume | 92 |
| Issue | 2 | Pages | 259-64 |
| PubMed ID | 22416256 | Mgi Jnum | J:186218 |
| Mgi Id | MGI:5431201 | Doi | 10.1189/jlb.1111569 |
| Citation | Takiishi T, et al. (2012) Early IL-10 production is essential for syngeneic graft acceptance. J Leukoc Biol 92(2):259-64 |
| abstractText | We performed a comparative study and evaluated cellular infiltrates and anti-inflammatory cytokine production at different time-points after syngeneic or allogeneic skin transplantation. We observed an early IL-10 production in syngeneic grafts compared with allografts. This observation prompted us to investigate the role of IL-10 in isograft acceptance. For this, we used IL-10 KO and WT mice to perform syngeneic transplantation, where IL-10 was absent in the graft or in the recipient. The majority of syngeneic grafts derived from IL-10 KO donors did not engraft or was only partially accepted, whereas IL-10 KO mice transplanted with skin from WT donors accepted the graft. We evaluated IL-10 producers in the transplanted skin and observed that epithelial cells were the major source. Taken together, our data show that production of IL-10 by donor cells, but not by the recipient, is determinant for graft acceptance and strongly suggest that production of this cytokine by keratinocytes immediately upon transplantation is necessary for isograft survival. |
