| First Author | Dai H | Year | 2010 |
| Journal | J Immunol | Volume | 185 |
| Issue | 2 | Pages | 803-7 |
| PubMed ID | 20548035 | Mgi Jnum | J:161937 |
| Mgi Id | MGI:4462080 | Doi | 10.4049/jimmunol.1000661 |
| Citation | Dai H, et al. (2010) Cutting edge: Programmed Death-1 defines CD8+ CD122+ T cells as regulatory versus memory T cells. J Immunol 185(2):803-7 |
| abstractText | Recent convincing data have shown that naturally occurring CD8(+)CD122(+) T cells are also regulatory T cells. Paradoxically, CD8(+)CD122(+) T cells have been well described as memory T cells. Given their critical role in tolerance versus long-term immunity, it is important to reconcile this profound dichotomy. In this study, we reported that CD8(+)CD122(+) T cells contain both programmed death-1 (PD-1)(-) and PD-1(+) populations. It was CD8(+)CD122(+)PD-1(+) T cells, but not their PD-1(-) counterparts, that suppressed T cell responses in vitro and in vivo. This suppression was largely dependent on their production of IL-10. Moreover, the costimulatory signaling of both CD28 and PD-1 is required for their optimal IL-10 production. In contrast, Ag-specific CD8(+)CD122(+)PD-1(-) T cells were bona fide memory T cells. Thus, CD8(+)CD122(+) T cells can be either regulatory T or memory T cells, depending on their PD-1 expression and Ag specificity. This study reconciles previously contradictory findings and has important implications for tolerance induction. |
