| First Author | Tullius SG | Year | 2014 |
| Journal | Nat Commun | Volume | 5 |
| Pages | 5101 | PubMed ID | 25290058 |
| Mgi Jnum | J:337571 | Mgi Id | MGI:6214418 |
| Doi | 10.1038/ncomms6101 | Citation | Tullius SG, et al. (2014) NAD+ protects against EAE by regulating CD4+ T-cell differentiation. Nat Commun 5:5101 |
| abstractText | CD4(+) T cells are involved in the development of autoimmunity, including multiple sclerosis (MS). Here we show that nicotinamide adenine dinucleotide (NAD(+)) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune homeostasis through CD4(+)IFNgamma(+)IL-10(+) T cells and reverses disease progression by restoring tissue integrity via remyelination and neuroregeneration. We show that NAD(+) regulates CD4(+) T-cell differentiation through tryptophan hydroxylase-1 (Tph1), independently of well-established transcription factors. In the presence of NAD(+), the frequency of T-bet(-/-) CD4(+)IFNgamma(+) T cells was twofold higher than wild-type CD4(+) T cells cultured in conventional T helper 1 polarizing conditions. Our findings unravel a new pathway orchestrating CD4(+) T-cell differentiation and demonstrate that NAD(+) may serve as a powerful therapeutic agent for the treatment of autoimmune and other diseases. |
