| First Author | Laidlaw BJ | Year | 2017 |
| Journal | Sci Immunol | Volume | 2 |
| Issue | 16 | PubMed ID | 29054998 |
| Mgi Jnum | J:329153 | Mgi Id | MGI:6869831 |
| Doi | 10.1126/sciimmunol.aan4767 | Citation | Laidlaw BJ, et al. (2017) Interleukin-10 from CD4(+) follicular regulatory T cells promotes the germinal center response. Sci Immunol 2(16):eaan4767 |
| abstractText | CD4(+) follicular regulatory T (Tfr) cells suppress B cell responses through modulation of follicular helper T (Tfh) cells and germinal center (GC) development. We found that Tfr cells can also promote the GC response through provision of interleukin-10 (IL-10) after acute infection with lymphocytic choriomeningitis virus (LCMV). Sensing of IL-10 by B cells was necessary for optimal development of the GC response. GC B cells formed in the absence of Treg cell-derived IL-10 displayed an altered dark zone state and decreased expression of the transcription factor Forkhead box protein 1 (FOXO1). IL-10 promoted nuclear translocation of FOXO1 in activated B cells. These data indicate that Tfr cells play a multifaceted role in the fine-tuning of the GC response and identify IL-10 as an important mediator by which Tfr cells support the GC reaction. |
