| First Author | Kapur R | Year | 2017 |
| Journal | Blood | Volume | 129 |
| Issue | 18 | Pages | 2557-2569 |
| PubMed ID | 28202460 | Mgi Jnum | J:241536 |
| Mgi Id | MGI:5902898 | Doi | 10.1182/blood-2016-12-758185 |
| Citation | Kapur R, et al. (2017) T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10. Blood 129(18):2557-2569 |
| abstractText | Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatalities and is characterized by acute respiratory distress following blood transfusion. Donor antibodies are frequently involved; however, the pathogenesis and protective mechanisms in the recipient are poorly understood, and specific therapies are lacking. Using newly developed murine TRALI models based on injection of anti-major histocompatibility complex class I antibodies, we found CD4+CD25+FoxP3+ T regulatory cells (Tregs) and CD11c+ dendritic cells (DCs) to be critical effectors that protect against TRALI. Treg or DC depletion in vivo resulted in aggravated antibody-mediated acute lung injury within 90 minutes with 60% mortality upon DC depletion. In addition, resistance to antibody-mediated TRALI was associated with increased interleukin-10 (IL-10) levels, and IL-10 levels were found to be decreased in mice suffering from TRALI. Importantly, IL-10 injection completely prevented and rescued the development of TRALI in mice and may prove to be a promising new therapeutic approach for alleviating lung injury in this serious complication of transfusion. |
