| First Author | Brooks DG | Year | 2006 |
| Journal | Nat Med | Volume | 12 |
| Issue | 11 | Pages | 1301-9 |
| PubMed ID | 17041596 | Mgi Jnum | J:115332 |
| Mgi Id | MGI:3691396 | Doi | 10.1038/nm1492 |
| Citation | Brooks DG, et al. (2006) Interleukin-10 determines viral clearance or persistence in vivo. Nat Med 12(11):1301-9 |
| abstractText | Persistent viral infections are a major health concern. One obstacle inhibiting the clearance of persistent infections is functional inactivation of antiviral T cells. Although such immunosuppression occurs rapidly after infection, the mechanisms that induce the loss of T-cell activity and promote viral persistence are unknown. Herein we document that persistent viral infection in mice results in a significant upregulation of interleukin (IL)-10 by antigen-presenting cells, leading to impaired T-cell responses. Genetic removal of Il10 resulted in the maintenance of robust effector T-cell responses, the rapid elimination of virus and the development of antiviral memory T-cell responses. Therapeutic administration of an antibody that blocks the IL-10 receptor restored T-cell function and eliminated viral infection. Thus, we identify a single molecule that directly induces immunosuppression leading to viral persistence and demonstrate that a therapy to neutralize IL-10 results in T-cell recovery and the prevention of viral persistence. |
