| First Author | Cantorna MT | Year | 2000 |
| Journal | J Nutr | Volume | 130 |
| Issue | 11 | Pages | 2648-52 |
| PubMed ID | 11053501 | Mgi Jnum | J:65513 |
| Mgi Id | MGI:1926684 | Doi | 10.1093/jn/130.11.2648 |
| Citation | Cantorna MT, et al. (2000) 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease. J Nutr 130(11):2648-52 |
| abstractText | Anecdotal data suggest that the amount of vitamin D available in the environment either from sunshine exposure or diet may be an important factor affecting the development of inflammatory bowel disease (IBD) in humans. We tested the vitamin D hypothesis in an experimental animal model of IBD. Interleukin (IL)-10 knockout (KO) mice, which spontaneously develop symptoms resembling human IBD, were made vitamin D deficient, vitamin D sufficient or supplemented with active vitamin D (1,25-dihydroxycholecalciferol). Vitamin D-deficient IL-10 KO mice rapidly developed diarrhea and a wasting disease, which induced mortality. In contrast, vitamin D-sufficient IL-10 KO mice did not develop diarrhea, waste or die. Supplementation with 50 IU of cholecalciferol (5.0 &mgr;g/d) or 1, 25-dihydroxycholecalciferol (0.005 &mgr;g/d) significantly (P: < 0. 05) ameliorated symptoms of IBD in IL-10 KO mice. 1, 25-Dihydroxycholecalciferol treatment (0.2 &mgr;g/d) for as little as 2 wk blocked the progression and ameliorated (P: < 0.05) symptoms in IL-10 KO mice with already established IBD. |
