| First Author | Spolski R | Year | 2009 |
| Journal | J Immunol | Volume | 182 |
| Issue | 5 | Pages | 2859-67 |
| PubMed ID | 19234181 | Mgi Jnum | J:146251 |
| Mgi Id | MGI:3837089 | Doi | 10.4049/jimmunol.0802978 |
| Citation | Spolski R, et al. (2009) IL-21 mediates suppressive effects via its induction of IL-10. J Immunol 182(5):2859-67 |
| abstractText | IL-21 is a pleiotropic cytokine that is required for normal Ig production. We previously showed that IL-21 was elevated in BXSB-Yaa mice with systemic lupus erythematosus. These mice also had elevated IL-10 levels, and we now show that IL-21 induces IL-10 mRNA and protein, suggesting unexpected immunosuppressive activities for IL-21. Indeed, Th1 priming with IL-21 leads to accumulation of cells with immunosuppressive activity, and IL-21 overexpression decreases specific Ab production after immunization in an IL-10-dependent fashion. Moreover, we show that IL-21 signaling is required for maximal induction of IL-10 by IL-6 or IL-27. Overall, our data indicate that IL-21 regulates immune responses at least in part by inducing IL-10 and reveal unanticipated immunosuppressive actions for this cytokine. |
