| First Author | Cedeno-Laurent F | Year | 2012 |
| Journal | J Immunol | Volume | 188 |
| Issue | 7 | Pages | 3127-37 |
| PubMed ID | 22345665 | Mgi Jnum | J:183114 |
| Mgi Id | MGI:5317498 | Doi | 10.4049/jimmunol.1103433 |
| Citation | Cedeno-Laurent F, et al. (2012) Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol 188(7):3127-37 |
| abstractText | Galectin-1 (Gal-1), a beta-galactoside-binding protein, can alter fate and effector function of Th cells; however, little is known about how Gal-1 induces Th cell differentiation. In this article, we show that both uncommitted and polarized Th cells bound by Gal-1 expressed an immunoregulatory signature defined by IL-10. IL-10 synthesis was stimulated by direct Gal-1 engagement to cell surface glycoproteins, principally CD45, on activated Th cells and enhanced by IL-21 expression through the c-Maf/aryl hydrocarbon receptor pathway, independent of APCs. Gal-1-induced IL-10(+) T cells efficiently suppressed T cell proliferation and T cell-mediated inflammation and promoted the establishment of cancer immune-privileged sites. Collectively, these findings show how Gal-1 functions as a major glycome determinant regulating Th cell development, inflammation, and tumor immunity. |
