| First Author | Esche C | Year | 1999 |
| Journal | J Invest Dermatol | Volume | 113 |
| Issue | 6 | Pages | 1028-32 |
| PubMed ID | 10594747 | Mgi Jnum | J:118447 |
| Mgi Id | MGI:3699585 | Doi | 10.1046/j.1523-1747.1999.00779.x |
| Citation | Esche C, et al. (1999) Differential regulation of epidermal and dermal dendritic cells by IL-12 and Flt3 ligand. J Invest Dermatol 113(6):1028-32 |
| abstractText | An abrogation of the decline in epidermal Langerhans cell numbers above melanoma might significantly improve the efficacy of immunotherapy for melanoma treatment. Systemic Flt3 ligand (FL) administration in mice induced a significant increase in mature dendritic cells (DC) within the skin, preferentially in the dermis, whereas IL-12 promoted a significant increase of immature DC preferentially in the epidermis. Both effects were abrogated in IL-12 knockout mice. Thus, IL-12 could promote FL-induced accumulation of skin DC. The involvement of FL and IL-12 in the regulation of DC accumulation within the skin may contribute, at least in part, to the stimulation of antimelanoma immunity by FL- and IL-12-based immunotherapies. Moreover, FL and IL-12 could be used for selective in vivo generation of DC in either epidermis or dermis for experimental and clinical purposes. |
