| First Author | McIntyre KW | Year | 1996 |
| Journal | Eur J Immunol | Volume | 26 |
| Issue | 12 | Pages | 2933-8 |
| PubMed ID | 8977288 | Mgi Jnum | J:37075 |
| Mgi Id | MGI:84479 | Doi | 10.1002/eji.1830261219 |
| Citation | McIntyre KW, et al. (1996) Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur J Immunol 26(12):2933-8 |
| abstractText | Collagen-induced arthritis (CIA) is an animal model for rheumatoid arthritis. The disease is elicited by immunization of genetically susceptible DBA/1 mice with type II collagen, resulting in a debilitating arthritis characterized by inflammation and involvement of multiple joints. We investigated the role of endogenous interleukin (IL)-12 in the pathogenesis of this disease by undertaking an analysis of IL-12-deficient mice on the DBA/1 genetic background after immunization with type II collagen. Both the incidence and severity of disease were significantly reduced in mice unable to produce biologically active IL-12. Concomitant decreases were observed in serum levels of pathogenic, collagen-specific IgG2a antibodies and collagen-induced secretion of interferon-gamma by immune splenocytes in vitro, consistent with an impaired T helper-1 response. There were, however, a few animals which developed severe disease in a single paw in spite of this highly diminished Th1 response. Taken together, these results demonstrate an important role for IL-12 in the pathogenesis of CIA, although it is not absolutely required for disease development. |
