| First Author | Duthie MS | Year | 2005 |
| Journal | Infect Immun | Volume | 73 |
| Issue | 3 | Pages | 1890-4 |
| PubMed ID | 15731095 | Mgi Jnum | J:96678 |
| Mgi Id | MGI:3531243 | Doi | 10.1128/IAI.73.3.1890-1894.2005 |
| Citation | Duthie MS, et al. (2005) Both CD1d antigen presentation and interleukin-12 are required to activate natural killer T cells during Trypanosoma cruzi infection. Infect Immun 73(3):1890-4 |
| abstractText | Mechanisms of natural killer T (NKT)-cell activation remain unclear. Here, we report that during Trypanosoma cruzi infection, interleukin-12 (IL-12) deficiency or anti-CD1d antibody treatment prevents normal activation. The required IL-12 arises independently of MyD88. The data support a model of normal NKT-cell activation that requires IL-12 and TCR stimulation. |
