| First Author | Yeh WI | Year | 2014 |
| Journal | J Neuroimmunol | Volume | 267 |
| Issue | 1-2 | Pages | 20-7 |
| PubMed ID | 24369297 | Mgi Jnum | J:325803 |
| Mgi Id | MGI:6872794 | Doi | 10.1016/j.jneuroim.2013.12.001 |
| Citation | Yeh WI, et al. (2014) IFNgamma inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms. J Neuroimmunol 267(1-2):20-7 |
| abstractText | The transcription factor Tbet is critical for the differentiation of Th1 CD4 T cells and is associated with the induction of multiple autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate that Tbet suppresses IL-17A and Th17 differentiation both in vitro and in vivo in a cell-intrinsic manner, and that in fact, Tbet is not necessary for EAE induction. Moreover, we find that IFNgamma inhibits the production of IL-17A and IL-17F in a STAT1-dependent, Tbet-independent manner. These findings illustrate multiple mechanisms utilized by developing Th1 cells to silence the Th17 program. |
