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Allele : Igh-J<tm1Dim> immunoglobulin heavy chain, joining region; targeted mutation 1, Diane Mathis

Primary Identifier  MGI:3626301 Allele Type  Targeted
Attribute String  Inserted expressed sequence Gene  Igh-J
Transmission  Germline Strain of Origin  129S4/SvJae-Tg(Prm-cre)70Og
Is Recombinase  false Is Wild Type  false
description  Targeting took place in ES cells that contain the Tg(Prm-cre)70Og transgene, which expresses Cre recombinase in male germ cells.
molecularNote  A targeting vector containing the mAb 6.121 VHDHJH sequence and a loxP-flanked neomycin resistance cassette was inserted into the locus to replace the JH region. Cre mediated recombination subsequently removed the neomycin cassette upon transmission from male chimeric mice.
  • mutations:
  • Insertion,
  • Intergenic deletion
  • synonyms:
  • H<121>,
  • H<121>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

4 Publication categories