| First Author | Eason DD | Year | 2003 |
| Journal | Oncogene | Volume | 22 |
| Issue | 40 | Pages | 6166-76 |
| PubMed ID | 13679855 | Mgi Jnum | J:85972 |
| Mgi Id | MGI:2677621 | Doi | 10.1038/sj.onc.1206563 |
| Citation | Eason DD, et al. (2003) Development of CD30+ lymphoproliferative disease in mice lacking interferon regulatory factor-1. Oncogene 22(40):6166-76 |
| abstractText | Human lymphomas continue to represent a major challenge in oncology, and in particular occur at very high frequencies in AIDS patients. We report here the development of a CD30+ lymphoproliferative disease in mice lacking the proapoptotic transcription factor, interferon regulatory factor-1. These mice most closely represent a model of human anaplastic large-cell lymphoma (ALCL). This mouse model of lymphoma will likely be useful in understanding the development of ALCL and in understanding the development of other closely related CD30+ forms of lymphoma, such as CD30+ Hodgkin's disease and CD30+ cutaneous T-cell lymphoma. This mouse model will also be useful in testing therapies for different forms of CD30+ lymphoma, in particular anti-CD30-based therapies. |
