| First Author | Kimura T | Year | 1994 |
| Journal | Science | Volume | 264 |
| Issue | 5167 | Pages | 1921-4 |
| PubMed ID | 8009222 | Mgi Jnum | J:18880 |
| Mgi Id | MGI:67102 | Doi | 10.1126/science.8009222 |
| Citation | Kimura T, et al. (1994) Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science 264(5167):1921-4 |
| abstractText | The mechanisms underlying interferon (IFN)-induced antiviral states are not well understood. Interferon regulatory factor-1 (IRF-1) is an IFN-inducible transcriptional activator, whereas IRF-2 suppresses IRF-1 action. The inhibition of encephalomyocarditis virus (EMCV) replication by IFN-alpha and especially by IFN-gamma was impaired in cells from mice with a null mutation in the IRF-1 gene (IRF-1-/- mice). The IRF-1-/- mice were less resistant than normal mice to EMCV infection, as revealed by accelerated mortality and a larger virus titer in target organs. The absence of IRF-1 did not clearly affect replication of two other types of viruses. Thus, IRF-1 is necessary for the antiviral action of IFNs against some viruses, but IFNs activate multiple activation pathways through diverse target genes to induce the antiviral state. |
