| First Author | Hagihara M | Year | 2022 |
| Journal | Cell Rep | Volume | 41 |
| Issue | 11 | Pages | 111755 |
| PubMed ID | 36516771 | Mgi Jnum | J:334658 |
| Mgi Id | MGI:7424702 | Doi | 10.1016/j.celrep.2022.111755 |
| Citation | Hagihara M, et al. (2022) Clostridium butyricum-induced omega-3 fatty acid 18-HEPE elicits anti-influenza virus pneumonia effects through interferon-lambda upregulation. Cell Rep 41(11):111755 |
| abstractText | The precise mechanism by which butyrate-producing bacteria in the gut contribute to resistance to respiratory viral infections remains to be elucidated. Here, we describe a gut-lung axis mechanism and report that orally administered Clostridium butyricum (CB) enhances influenza virus infection resistance through upregulation of interferon (IFN)-lambda in lung epithelial cells. Gut microbiome-induced omega-3 fatty acid 18-hydroxy eicosapentaenoic acid (18-HEPE) promotes IFN-lambda production through the G protein-coupled receptor (GPR)120 and IFN regulatory factor (IRF)-1/-7 activations. CB promotes 18-HEPE production in the gut and enhances omega-3 fatty acid sensitivity in the lungs by promoting GPR120 expression. This study finds a gut-lung axis mechanism and provides insights into the treatments and prophylaxis for viral respiratory infections. |
