| First Author | Arroyo AG | Year | 1996 |
| Journal | Cell | Volume | 85 |
| Issue | 7 | Pages | 997-1008 |
| PubMed ID | 8674127 | Mgi Jnum | J:33881 |
| Mgi Id | MGI:81374 | Doi | 10.1016/s0092-8674(00)81301-x |
| Citation | Arroyo AG, et al. (1996) Differential requirements for alpha4 integrins during fetal and adult hematopoiesis. Cell 85(7):997-1008 |
| abstractText | Mice chimeric for the expression of alpha4 integrins were used to dissect the roles of these receptors in development and traffic of lymphoid and myeloid cells. During fetal life, T cell development is alpha4 independent, but after birth further production of T cells becomes alpha4 dependent. Precursors for both T and B cells require alpha4 integrins for normal development within the bone marrow. In contrast, monocytes and natural killer cells can develop normally without alpha4 integrins. Thus, there are lymphocyte-specific, developmentally regulated requirements for alpha4 integrins in hematopoiesis in the bone marrow. We also show that alpha4 integrins are essential for T cell homing to Peyer's patches, but not to other secondary lymphoid organs, including spleen, lymph nodes, and intestinal epithelium. |
