| First Author | Wu G | Year | 1996 |
| Journal | Int Immunol | Volume | 8 |
| Issue | 7 | Pages | 1159-64 |
| PubMed ID | 8757961 | Mgi Jnum | J:37930 |
| Mgi Id | MGI:85325 | Doi | 10.1093/intimm/8.7.1159 |
| Citation | Wu G, et al. (1996) Lck dependence of signaling pathways activated by gamma-irradiation and CD3 epsilon engagement in RAG-1(-/-)-immature thymocytes. Int Immunol 8(7):1159-64 |
| abstractText | The src family tyrosine kinase, Lck, transduces signals from the pre-TCR complex which regulate the development and expansion of CD4/CD8 double-positive (DP) thymocytes from CD25(+) CD4/CD8 double-negative progenitors. We and others have recently shown that sublethal gamma-irradiation bypasses the need for TCRbeta expression to promote the development and expansion of DP thymocytes in scid or recombinase-activating gene (RAG)-deficient mice. Here we demonstrate that gamma-irradiation activates an Lck-dependent signaling process in immature thymocytes similar to that initiated physiologically by the pre-TCR complex. |
