| First Author | Kawai K | Year | 1995 |
| Journal | J Exp Med | Volume | 181 |
| Issue | 1 | Pages | 345-9 |
| PubMed ID | 7807014 | Mgi Jnum | J:22470 |
| Mgi Id | MGI:70338 | Doi | 10.1084/jem.181.1.345 |
| Citation | Kawai K, et al. (1995) Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice. J Exp Med 181(1):345-9 |
| abstractText | To determine whether p56lck protein tyrosine kinase and CD45 protein tyrosine phosphatase are involved in the signal transduction during intrathymic differentiation of gamma/delta T cells, we have examined the development of T cells expressing V gamma 3 T cell receptor (TCR) in mice deficient for either protein. The skin from both mice contained significantly reduced numbers of dendritic epidermal T cells expressing decreased levels of V gamma 3 TCR at the cell surface. Analysis of the fetal thymus from these mice suggested that maturation of V gamma 3 thymocytes was blocked at the immature stage that was characterized by the low level of V gamma 3 TCR and the high level of heat stable antigen. These results imply that both p56lck and CD45 are involved in the signal transduction during maturation of V gamma 3 T cells in the fetal thymus. |
