| First Author | Seddon B | Year | 2000 |
| Journal | Science | Volume | 290 |
| Issue | 5489 | Pages | 127-31 |
| PubMed ID | 11021796 | Mgi Jnum | J:65101 |
| Mgi Id | MGI:1891778 | Doi | 10.1126/science.290.5489.127 |
| Citation | Seddon B, et al. (2000) Long-term survival but impaired homeostatic proliferation of Naive T cells in the absence of p56(lck). Science 290(5489):127-31 |
| abstractText | Interactions between the T cell receptor (TCR) and major histocompatibility complex antigens are essential for the survival and homeostasis of peripheral T lymphocytes. However, little is known about the TCR signaling events that result from these interactions. The peripheral T cell pool of p56(lck) (lck)-deficient mice was reconstituted by the expression of an inducible lck transgene. Continued survival of peripheral naive T cells was observed for long periods after switching off the transgene. Adoptive transfer of T cells from these mice into T lymphopoienic hosts confirmed that T cell survival was independent of lck but revealed its essential role in TCR-driven homeostatic proliferation of naive T cells in response to the T cell-deficient host environment. These data suggest that survival and homeostatic expansion depend on different signals. |
