| First Author | Trobridge PA | Year | 2001 |
| Journal | Eur J Immunol | Volume | 31 |
| Issue | 12 | Pages | 3567-79 |
| PubMed ID | 11745376 | Mgi Jnum | J:128169 |
| Mgi Id | MGI:3766356 | Doi | 10.1002/1521-4141(200112)31:12<3567::aid-immu3567>3.0.co;2-m |
| Citation | Trobridge PA, et al. (2001) Lck plays a critical role in Ca(2+) mobilization and CD28 costimulation in mature primary T cells. Eur J Immunol 31(12):3567-79 |
| abstractText | To investigate the signaling function of the Src-family protein tyrosine kinase Lck in mature T cells, we generated transgenic mice that expressed Lck in thymocytes but not in peripheral lymphocytes. We compared the phenotype and signaling capacity of Lck-deficient T cells with T cells from mice expressing a dominant inhibitory form of Lck and found that both mouse strains have diminished numbers of mature CD8(+) T cells and respond poorly to CD28 costimulation. However, while T cells that lack Lck fail to mobilize Ca(2+) after stimulation, those expressing the dominant negative protein do so normally. Our data demonstrate that Lck plays several unique roles in mature lymphocyte signaling. |
