Primary Identifier | MGI:7277696 | Allele Type | Endonuclease-mediated |
Attribute String | Humanized sequence | Gene | Slc7a14 |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Using an sgRNA and an ssODN template with CRISPR/Cas9 technology, glycine codon 330 (GGC) in exon 6 was changed to arginine (AGG) (c.988_990delGGCinsAGG, p.G330R). This mimics the human p.G330R mutation associated with progressive sensorineural hearing loss and retinitis pigmentosa (RP). |