| First Author | Aslanian AM | Year | 2005 |
| Journal | Arterioscler Thromb Vasc Biol | Volume | 25 |
| Issue | 3 | Pages | 628-32 |
| PubMed ID | 15591216 | Mgi Jnum | J:110061 |
| Mgi Id | MGI:3639053 | Doi | 10.1161/01.ATV.0000153046.59370.13 |
| Citation | Aslanian AM, et al. (2005) Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions. Arterioscler Thromb Vasc Biol 25(3):628-32 |
| abstractText | OBJECTIVE: CD1d-restricted natural killer T (NKT) cells are reported to play a proatherogenic role in the development of atherosclerosis. However, the contribution of NKT cells to mature lesion formation and the effector mechanisms through which they act are unknown. METHODS AND RESULTS: We measured lesion size in CD1d-null (CD1d-/-) mice on the low-density lipoprotein (LDL) receptor-deficient (LDLR-/-) genetic background after 4, 8, and 12 weeks of feeding on a Western diet. Lesions in CD1d-/-LDLR-/- mice were 47% smaller at 4 weeks than CD1d+/+LDLR-/- controls; however, there were no differences in lesion size between CD1d-/-LDLR-/- and CD1d+/+LDLR-/- mice at 8 or 12 weeks. We found that although NKT cells were present in the aortic arch of CD1d+/+LDLR-/- mice on the Western diet, no differences in mRNA abundance for Th1 or Th2 cytokines were observed between CD1d-/-LDLR-/- and CD1d+/+LDLR-/- mice. CONCLUSIONS: CD1d-restricted NKT cells contribute to the formation of fatty streaks; however, their influence on lesion progression is transient, and they do not significantly affect the inflammatory cytokine milieu of mature lesions. |
