| First Author | Wood EG | Year | 2020 |
| Journal | Sci Rep | Volume | 10 |
| Issue | 1 | Pages | 20825 |
| PubMed ID | 33257753 | Mgi Jnum | J:299603 |
| Mgi Id | MGI:6491036 | Doi | 10.1038/s41598-020-77793-6 |
| Citation | Wood EG, et al. (2020) HIF1alpha activation in dendritic cells under sterile conditions promotes an anti-inflammatory phenotype through accumulation of intracellular lipids. Sci Rep 10(1):20825 |
| abstractText | Obesity is among the leading causes of elevated cardiovascular disease mortality and morbidity. Adipose tissue dysfunction, insulin resistance and inflammation are recognized as important risk factors for the development of cardiovascular disorders in obesity. Hypoxia appears to be a key factor in adipose tissue dysfunction affecting not only adipocytes but also immune cell function. Here we examined the effect of hypoxia-induced transcription factor HIF1alpha activation on classical dendritic cell (cDCs) function during obesity. We found that deletion of Hif1alpha on cDCs results in enhanced adipose-tissue inflammation and atherosclerotic plaque formation in a mouse model of obesity. This effect is mediated by HIF1alpha-mediated increased lipid synthesis, accumulation of lipid droplets and alter synthesis of lipid mediators. Our findings demonstrate that HIF1alpha activation in cDCs is necessary to control vessel wall inflammation. |
