| First Author | Martos-Folgado I | Year | 2022 |
| Journal | Cell Rep | Volume | 41 |
| Issue | 2 | Pages | 111468 |
| PubMed ID | 36223741 | Mgi Jnum | J:330180 |
| Mgi Id | MGI:7366845 | Doi | 10.1016/j.celrep.2022.111468 |
| Citation | Martos-Folgado I, et al. (2022) MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses. Cell Rep 41(2):111468 |
| abstractText | Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction, and stroke and is the leading cause of mortality worldwide. Immunization of pro-atherogenic mice with malondialdehyde-modified low-density lipoprotein (MDA-LDL) neo-antigen is athero-protective. However, the immune response to MDA-LDL and the mechanisms responsible for this athero-protection are not completely understood. Here, we find that immunization of mice with MDA-LDL elicits memory B cells, plasma cells, and switched anti-MDA-LDL antibodies as well as clonal expansion and affinity maturation, indicating that MDA-LDL triggers a bona fide germinal center antibody response. Further, Prdm1(fl/fl)Aicda-Cre(+/ki)Ldlr(-/-) pro-atherogenic chimeras, which lack germinal center-derived plasma cells, show accelerated atherosclerosis. Finally, we show that MDA-LDL immunization is not athero-protective in mice lacking germinal-center-derived plasma cells. Our findings give further support to the development of MDA-LDL-based vaccines for the prevention or treatment of atherosclerosis. |
