| First Author | Cassim Bawa FN | Year | 2022 |
| Journal | Cells | Volume | 11 |
| Issue | 20 | PubMed ID | 36291054 |
| Mgi Jnum | J:330958 | Mgi Id | MGI:7383360 |
| Doi | 10.3390/cells11203186 | Citation | Cassim Bawa FN, et al. (2022) Retinoic Acid Receptor Alpha (RARalpha) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice. Cells 11(20) |
| abstractText | Retinoic acid signaling plays an important role in regulating lipid metabolism and inflammation. However, the role of retinoic acid receptor alpha (RARalpha) in atherosclerosis remains to be determined. In the current study, we investigated the role of macrophage RARalpha in the development of atherosclerosis. Macrophages isolated from myeloid-specific Raralpha(-/-) (Raralpha(Mac-/-)) mice showed increased lipid accumulation and inflammation and reduced cholesterol efflux compared to Raralpha(fl/fl) (control) mice. All-trans retinoic acid (AtRA) induced ATP-binding cassette subfamily A member 1 (Abca1) and Abcg1 expression and cholesterol efflux in both Raralpha(Mac-/-) mice and Raralpha(fl/fl) mice. In Ldlr(-/-) mice, myeloid ablation of RARalpha significantly reduced macrophage Abca1 and Abcg1 expression and cholesterol efflux, induced inflammatory genes, and aggravated Western diet-induced atherosclerosis. Our data demonstrate that macrophage RARalpha protects against atherosclerosis, likely via inducing cholesterol efflux and inhibiting inflammation. |
