| First Author | Koni PA | Year | 1998 |
| Journal | J Exp Med | Volume | 187 |
| Issue | 12 | Pages | 1977-83 |
| PubMed ID | 9625757 | Mgi Jnum | J:110881 |
| Mgi Id | MGI:3641485 | Doi | 10.1084/jem.187.12.1977 |
| Citation | Koni PA, et al. (1998) A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development: genetic evidence of synergism with lymphotoxin beta. J Exp Med 187(12):1977-83 |
| abstractText | Lymphotoxin alpha (LTalpha) signals via tumor necrosis factor receptors (TNFRs) as a homotrimer and via lymphotoxin beta receptor (LTbetaR) as a heterotrimeric LTalpha1beta2 complex. LTalpha-deficient mice lack all lymph nodes (LNs) and Peyer's patches (PPs), and yet LTbeta-deficient mice and TNFR-deficient mice have cervical and mesenteric LN. We now show that mice made deficient in both LTbeta and TNFR type 1 (TNFR1) lack all LNs, revealing redundancy or synergism between TNFR1 and LTbeta, acting presumably via LTbetaR. A complete lack of only PPs in mice heterozygous for both ltalpha and ltbeta, but not ltalpha or ltbeta alone, suggests a similar two-ligand phenomenon in PP development and may explain the incomplete lack of PPs seen in tnfr1-/- mice. |
