| First Author | Tumanov AV | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 1 | Pages | 86-91 |
| PubMed ID | 15210762 | Mgi Jnum | J:90815 |
| Mgi Id | MGI:3044827 | Doi | 10.4049/jimmunol.173.1.86 |
| Citation | Tumanov AV, et al. (2004) Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer's patches. J Immunol 173(1):86-91 |
| abstractText | Organogenesis of Peyer's patches (PP), follicle-associated epithelium, and M cells is impaired in mice lacking B cells. At the same time, lymphotoxin (LT) and TNF are known to be critical for the development of PP. To directly address the function of LT and TNF expressed by B cells in the maintenance of PP structure, we studied the de novo formation of PP in B cell-deficient mice after the transfer of bone marrow from mice with targeted mutations in LT, TNF, or their combinations. We found that although the compartmentalization of T and B cell zones and development of follicular dendritic cells were affected by the lack of B cell-derived LT and TNF, the development of follicle-associated epithelium and M cells in PP was completely independent of LT/TNF production by B cells. |
