| First Author | Rennert PD | Year | 1998 |
| Journal | Immunity | Volume | 9 |
| Issue | 1 | Pages | 71-9 |
| PubMed ID | 9697837 | Mgi Jnum | J:48789 |
| Mgi Id | MGI:1275822 | Doi | 10.1016/s1074-7613(00)80589-0 |
| Citation | Rennert PD, et al. (1998) Lymph node genesis is induced by signaling through the lymphotoxin beta receptor. Immunity 9(1):71-9 |
| abstractText | We investigated lymphotoxin (LT) and TNF function in lymph node genesis and cellular organization by manipulating LTbeta-R and TNF-R signaling. Lymph nodes developed in LTalpha-/- mice treated in utero with agonist anti-LTbeta-R monoclonal antibody. Thus, LTbeta-R signaling mediates lymph node genesis. Surprisingly, mucosal lymph nodes that can develop independently of LTalphabeta/LTbeta-R interaction were generated. Normal mice treated in utero with LTbeta-R-Ig and TNF-R55-Ig or anti-TNF lacked all lymph nodes, indicating that TNF signaling contributes to lymph node genesis. Lymph nodes generated in LTalpha-/- mice had disrupted cellular organization. There-fore, LTbeta-R signaling during gestation is not sufficient to establish normal cellular microarchi-tecture. We conclude that LT and TNF play critical roles in the genesis and cellular organization of lymph nodes. |
