First Author | Matsumoto M | Year | 1996 |
Journal | Science | Volume | 271 |
Issue | 5253 | Pages | 1289-91 |
PubMed ID | 8638112 | Mgi Jnum | J:63530 |
Mgi Id | MGI:1861127 | Doi | 10.1126/science.271.5253.1289 |
Citation | Matsumoto M, et al. (1996) Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science 271(5253):1289-91 |
abstractText | In mice deficient in either lymphotoxin-alpha (LT-alpha) or the type I tumor necrosis factor (TNF) receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral lymphoid organs. Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow. |