| First Author | Truman LA | Year | 2020 |
| Journal | Eur J Immunol | Volume | 50 |
| Issue | 3 | Pages | 418-425 |
| PubMed ID | 32012252 | Mgi Jnum | J:288847 |
| Mgi Id | MGI:6416350 | Doi | 10.1002/eji.201948300 |
| Citation | Truman LA, et al. (2020) Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production. Eur J Immunol 50(3):418-425 |
| abstractText | To investigate the role of lymphotoxin (LT) in Sjogren's syndrome (SS) and in mucosal associated lymphoid tissue (MALT)-lymphoma, we made transgenic mice (Amy1-LTalphabeta) that targeted LTalpha and LTbeta to the salivary and lacrimal glands. Amy1-LTalphabeta mice developed atrophic salivary and lacrimal glands that contained tertiary lymphoid organs (TLOs) and had reduced tear production. Amy1-LTalphabeta mice developed cervical lymphadenopathy but not MALT-lymphoma. TLO formation in the salivary and lacrimal glands of Amy1-LTalphabeta was not sufficient to induce autoimmunity as measured by autoantibody titres. |
