| Primary Identifier | MGI:1857219 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Myf5 |
| Transmission | Germline | Strain of Origin | 129S4/SvJae |
| Is Recombinase | false | Is Wild Type | false |
| description | Mice homozygous for Myf6 mutations lack or show reduced Myf5 expression and exhibit phenotypes seen in Myf5tm1Jae homozygotes. Studies have shown that Myf6 may regulate Myf5 expression by a cis-acting mechanism and that the skeletal abnormalities seen in Myf6 homozygotes may result from a decrease or lack of Myf5 expression (J:24360, J:31636). |
| molecularNote | A PGK-neomycin cassette was inserted into exon 1 of the gene, disrupting the reading frame. |
