| First Author | Wang R | Year | 2022 |
| Journal | Nat Commun | Volume | 13 |
| Issue | 1 | Pages | 205 |
| PubMed ID | 35017543 | Mgi Jnum | J:321314 |
| Mgi Id | MGI:6857166 | Doi | 10.1038/s41467-021-27865-6 |
| Citation | Wang R, et al. (2022) MyoD is a 3D genome structure organizer for muscle cell identity. Nat Commun 13(1):205 |
| abstractText | The genome exists as an organized, three-dimensional (3D) dynamic architecture, and each cell type has a unique 3D genome organization that determines its cell identity. An unresolved question is how cell type-specific 3D genome structures are established during development. Here, we analyzed 3D genome structures in muscle cells from mice lacking the muscle lineage transcription factor (TF), MyoD, versus wild-type mice. We show that MyoD functions as a "genome organizer" that specifies 3D genome architecture unique to muscle cell development, and that H3K27ac is insufficient for the establishment of MyoD-induced chromatin loops in muscle cells. Moreover, we present evidence that other cell lineage-specific TFs might also exert functional roles in orchestrating lineage-specific 3D genome organization during development. |
