| First Author | Shintaku J | Year | 2016 |
| Journal | Cell Rep | Volume | 17 |
| Issue | 2 | Pages | 514-526 |
| PubMed ID | 27705798 | Mgi Jnum | J:240658 |
| Mgi Id | MGI:5888845 | Doi | 10.1016/j.celrep.2016.09.010 |
| Citation | Shintaku J, et al. (2016) MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-kappaB. Cell Rep 17(2):514-526 |
| abstractText | MyoD is a key regulator of skeletal myogenesis that directs contractile protein synthesis, but whether this transcription factor also regulates skeletal muscle metabolism has not been explored. In a genome-wide ChIP-seq analysis of skeletal muscle cells, we unexpectedly observed that MyoD directly binds to numerous metabolic genes, including those associated with mitochondrial biogenesis, fatty acid oxidation, and the electron transport chain. Results in cultured cells and adult skeletal muscle confirmed that MyoD regulates oxidative metabolism through multiple transcriptional targets, including PGC-1beta, a master regulator of mitochondrial biogenesis. We find that PGC-1beta expression is cooperatively regulated by MyoD and the alternative NF-kappaB signaling pathway. Bioinformatics evidence suggests that this cooperativity between MyoD and NF-kappaB extends to other metabolic genes as well. Together, these data identify MyoD as a regulator of the metabolic capacity of mature skeletal muscle to ensure that sufficient energy is available to support muscle contraction. |
